Polyoxometalates as Inhibitors of the Aggregation of Amyloid β Peptides Associated with Alzheimer’s Disease

Authors

  • Jie Geng,

    1. Division of Biological Inorganic Chemistry, State Key Laboratory of Rare Earth Resource Utilization, Laboratory of Chemical Biology, Changchun Institute of Applied Chemistry, Graduate School of the Chinese Academy of Sciences, Changchun, Jilin 130022 (China)
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  • Meng Li,

    1. Division of Biological Inorganic Chemistry, State Key Laboratory of Rare Earth Resource Utilization, Laboratory of Chemical Biology, Changchun Institute of Applied Chemistry, Graduate School of the Chinese Academy of Sciences, Changchun, Jilin 130022 (China)
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  • Prof. Jinsong Ren,

    1. Division of Biological Inorganic Chemistry, State Key Laboratory of Rare Earth Resource Utilization, Laboratory of Chemical Biology, Changchun Institute of Applied Chemistry, Graduate School of the Chinese Academy of Sciences, Changchun, Jilin 130022 (China)
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  • Prof. Enbo Wang,

    1. Key Laboratory of Polyoxometalate Science of the Ministry of Education, Department of Chemistry, Northeast Normal University, Changchun, Jilin 130024 (China)
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  • Prof. Xiaogang Qu

    Corresponding author
    1. Division of Biological Inorganic Chemistry, State Key Laboratory of Rare Earth Resource Utilization, Laboratory of Chemical Biology, Changchun Institute of Applied Chemistry, Graduate School of the Chinese Academy of Sciences, Changchun, Jilin 130022 (China)
    • Division of Biological Inorganic Chemistry, State Key Laboratory of Rare Earth Resource Utilization, Laboratory of Chemical Biology, Changchun Institute of Applied Chemistry, Graduate School of the Chinese Academy of Sciences, Changchun, Jilin 130022 (China)
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  • We acknowledge financial support through the 973 Project (2011CB936004), by the NSFC (20831003, 90813001, 20833006, 90913007, 20903086), and by the Chinese Academy of Sciences.

Abstract

original image

Inorganic amyloid inhibitors: Four types of polyoxometalates (POMs) were found to be efficient inhibitors of amyloid formation by amyloid β peptides (Aβ; see picture: unlike the top POM (red), the bottom POM (dark green) inhibited amyloid formation). The inhibition selectivity of POMs is due to size-specific electrostatic interactions between POMs and Aβ through binding to the positively charged His13–Lys16 cluster region of Aβ.

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