We are grateful to the NIH (NIGMS GM-59417 and GM-64451) for financial support of this work.
A Boron-Based Synthesis of the Natural Product (+)-trans-Dihydrolycoricidine†
Article first published online: 31 MAR 2011
Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 50, Issue 18, pages 4189–4192, April 26, 2011
How to Cite
Poe, S. L. and Morken, J. P. (2011), A Boron-Based Synthesis of the Natural Product (+)-trans-Dihydrolycoricidine. Angew. Chem. Int. Ed., 50: 4189–4192. doi: 10.1002/anie.201007135
- Issue published online: 20 APR 2011
- Article first published online: 31 MAR 2011
- Manuscript Received: 12 NOV 2010
- NIH. Grant Numbers: GM-59417, GM-64451
- asymmetric synthesis;
- natural products;
Diastereoselective diboration results in the highly selective 1,4-dihydroxylation of chiral cyclohexadienes (see scheme). Together with the catalytic enantioselective conjugate allylboration, the diene diboration facilitates the asymmetric synthesis of the cytotoxic agent (+)-trans-dihydrolycoricidine (1). pin=pinacol.