SEARCH

SEARCH BY CITATION

Keywords:

  • boronic acids;
  • chemical ligation;
  • nucleic acids;
  • self-assembly;
  • templated synthesis
Thumbnail image of graphical abstract

Plug and play: A helix with a boronate ester linkage was constructed by DNA- or RNA-templated assembly through the plugging together of appropriately designed half-sequences, one with a boronic acid at its 5′ end, the other with a ribonucleotide at its 3′ end. The two hybridization steps in the three-component assembly (see picture) could be controlled reversibly by external stimuli, including an acid or base, cyanide ions, or fructose.