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Keywords:

  • carbonylation;
  • C[BOND]C coupling;
  • copper;
  • heterocycles;
  • multicomponent reactions
Thumbnail image of graphical abstract

One step back, two steps forward! Starting from diverse heterocycles, the title reaction furnishes ynediones under very mild conditions in a direct and preparatively simple one-pot process. The key to avoiding decarbonylation is the CuI-catalyzed Stephens–Castro alkynylation rather than the usually more efficient Sonogashira coupling. In addition, novel highly atom-economical four-component syntheses of various heterocycles can be achieved.