This research was supported by start-up funds from the University of California, Davis, the Petroleum Research Fund (administered by the ACS), and the NIH/NIAID (R56AI80931-01 & R01AI080931-01). This work was initiated at the Broad Institute of Harvard and MIT, where it was supported by the NIH/NIAID (R03 AI062905-01) and the Scientific Planning and Allocation of Resources Committee (SPARC). M.G.L. thanks the Fundación Ramon Areces for a postdoctoral fellowship. The authors thank Prof. Jon Clardy (Harvard Medical School) for helpful discussions, Prof. Dean Tantillo for DFT calculations, and Dr. Sheo Singh (Merck Research Laboratories) for providing copies of NMR spectra for viriditoxin.
Synthesis of (−)-Viriditoxin: A 6,6′-Binaphthopyran-2-one that Targets the Bacterial Cell Division Protein FtsZ†
Article first published online: 16 MAR 2011
Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 50, Issue 16, pages 3730–3733, April 11, 2011
How to Cite
Park, Y. S., Grove, C. I., González-López, M., Urgaonkar, S., Fettinger, J. C. and Shaw, J. T. (2011), Synthesis of (−)-Viriditoxin: A 6,6′-Binaphthopyran-2-one that Targets the Bacterial Cell Division Protein FtsZ. Angew. Chem. Int. Ed., 50: 3730–3733. doi: 10.1002/anie.201007298
- Issue published online: 5 APR 2011
- Article first published online: 16 MAR 2011
- Manuscript Received: 19 NOV 2010
- University of California, Davis
- Petroleum Research Fund
- NIH/NIAID. Grant Numbers: R56AI80931-01, R01AI080931-01, R03 AI062905-01
- Scientific Planning and Allocation of Resources Committee (SPARC)
- Merck Research Laboratories
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