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Transition-Metal-Free Intramolecular Ullmann-Type O-Arylation: Synthesis of Chromone Derivatives


  • The authors wish to thank the National Natural Science Foundation of China (Grant No. 20972083) and the Ministry of Science and Technology of China (2009ZX09501-004) for financial support.


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Expect the upexpected: A transition-metal-free approach to access chromone derivatives has been developed. The intramolecular O-arylation of substituted 1-(2-haloaryl)-propane-1,3-diones in DMF in the presence of K2CO3 gave the corresponding target products in good to excellent yields (see scheme; DMF=N,N′-dimethylformamide).