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Keywords:

  • allylic fluorination;
  • fluorides;
  • homogeneous catalysis;
  • palladium;
  • positron emission tomography
Thumbnail image of graphical abstract

Mild and rapid: The title reaction is presented and its applicability to 18F radiolabeling is demonstrated (see scheme; TBAF=tetra-n-butylammonium fluoride, THF=tetrahydrofuran, dba=dibenzylideneacetone). The use of p-nitrobenzoate as the leaving group is significant to the success of this catalytic organometallic fluorination process. A range of allylic fluorides were synthesized by this method.