Palladium-Catalyzed Allylic Fluorination


  • We thank Dr. S. Fletcher for very helpful discussions. This research was financially supported by the EPSRC (C.H., A.H., M.T.), GSK (M.H.), the CRUK (M.T.), the European Union FP7-ITN-238434 (E.B.), and the Leverhulme Trust (J.M.B.).


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Mild and rapid: The title reaction is presented and its applicability to 18F radiolabeling is demonstrated (see scheme; TBAF=tetra-n-butylammonium fluoride, THF=tetrahydrofuran, dba=dibenzylideneacetone). The use of p-nitrobenzoate as the leaving group is significant to the success of this catalytic organometallic fluorination process. A range of allylic fluorides were synthesized by this method.