Get access

Laser-Induced Cell Detachment and Patterning with Photodegradable Polymer Substrates

Authors

  • Dr. George Pasparakis,

    Corresponding author
    1. Institute of Electronic Structure and Laser (IESL), Foundation for Research and Technology—Hellas (FORTH), P.O. Box 1527, 71110 Heraklion, Crete (Greece), Fax: (+30) 2810-391-305
    • Institute of Electronic Structure and Laser (IESL), Foundation for Research and Technology—Hellas (FORTH), P.O. Box 1527, 71110 Heraklion, Crete (Greece), Fax: (+30) 2810-391-305
    Search for more papers by this author
  • Theodore Manouras,

    1. Institute of Microelectronics, NCSR Demokritos, 15310 Aghia Paraskevi, Attiki (Greece)
    Search for more papers by this author
  • Dr. Alexandros Selimis,

    1. Institute of Electronic Structure and Laser (IESL), Foundation for Research and Technology—Hellas (FORTH), P.O. Box 1527, 71110 Heraklion, Crete (Greece), Fax: (+30) 2810-391-305
    Search for more papers by this author
  • Dr. Maria Vamvakaki,

    1. Institute of Electronic Structure and Laser (IESL), Foundation for Research and Technology—Hellas (FORTH), P.O. Box 1527, 71110 Heraklion, Crete (Greece), Fax: (+30) 2810-391-305
    2. Department of Materials Science and Technology, University of Crete, 71003 Heraklion, Crete (Greece)
    Search for more papers by this author
  • Dr. Panagiotis Argitis

    1. Institute of Microelectronics, NCSR Demokritos, 15310 Aghia Paraskevi, Attiki (Greece)
    Search for more papers by this author

  • We gratefully acknowledge Thomas Papastathis for his help with the chamber design and Apostolos Englezis for his advice on the laser optics and setup.

Abstract

original image

A glimpse of light is all it takes: Polymers that undergo main-chain scission at remarkably low photolysis energies were developed as efficient photodegradable substrates for safe laser-mediated cell detachment and patterning. The polymers, which contain acetal or ketal units in their backbone along with suitable absorbing groups, underwent fast degradation to release live cells upon irradiation with an excimer laser (see picture).

Get access to the full text of this article

Ancillary