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Luminescent Gold Nanoparticles with Efficient Renal Clearance


  • This work was supported in part by the NIH (R21EB009853 to J.Z.) and the start-up fund from the University of Texas at Dallas (J.Z.). We would like to thank Dr. A. Dean Sherry and Dr. Li Liu at the UT Southwestern Medical Center for insightful discussion. C.Z. thanks Dr. Jinbin Liu at UT Dallas for teaching gel electrophoresis.


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Going to waste: Renal clearance of 2 nm glutathione-coated luminescent gold nanoparticles (GS-AuNPs) was more than 10 to 100 times better than that of the similarly sized nonluminescent AuNPs coated by bis(p-sulfonatophenyl)phenylphosphine and cysteine. Urinary excretion of the particles was imaged with X-ray computed tomography (see picture of a mouse after injection of GS-AuNPs) and luminescence techniques in real time.

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