Tunable Synthesis of Encapsulated Microbubbles by Coupled Electrophoretic Stabilization and Electrochemical Inflation

Authors

  • Yu-Wen Huang,

    1. Artie McFerrin Department of Chemical Engineering, Texas A&M University, 3122 TAMU, College Station, TX 77843 (USA), Fax: (+1) 979-458-1002
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  • Faisal A. Shaikh,

    1. Artie McFerrin Department of Chemical Engineering, Texas A&M University, 3122 TAMU, College Station, TX 77843 (USA), Fax: (+1) 979-458-1002
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  • Prof. Victor M. Ugaz

    Corresponding author
    1. Artie McFerrin Department of Chemical Engineering, Texas A&M University, 3122 TAMU, College Station, TX 77843 (USA), Fax: (+1) 979-458-1002
    • Artie McFerrin Department of Chemical Engineering, Texas A&M University, 3122 TAMU, College Station, TX 77843 (USA), Fax: (+1) 979-458-1002
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  • This work was supported in part by the Camille & Henry Dreyfus Foundation and the US National Science Foundation (NSF) under grant CTS-0554108. We thank Prof. Gyula Vigh for graciously providing cyclodextran samples, as well as for many helpful discussions. We also thank the staff in the Materials Characterization Facility (MCF) and the Microscopy & Imaging Center (MIC) at Texas A&M. V.M.U. gratefully acknowledges support from the K. R. Hall Professorship at Texas A&M.

Abstract

original image

Visible to the naked eye: An interplay between microscale electrophoresis and electrochemistry was exploited to simultaneously confine macromolecular encapsulants near an electrode surface while inflating them with gases evolved from the electrochemical reactions localized there. The compacted film can be seen under ordinary white light even when samples are unlabeled thus enabling a label-free technique for the detection of a variety of macromolecules including DNA, proteins, and cyclodextrans.

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