Efficient Hydrogenation of Ketones Catalyzed by an Iron Pincer Complex


  • This research was supported by the European Research Council under the FP7 framework (ERC No 246837) and by the MINERVA Foundation. R.L. received a postdoctoral fellowship from the Deutsche Forschungsgemeinschaft (DFG). D.M. holds the Israel Matz Professorial Chair of Organic Chemistry.


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Reductions made easy: A highly efficient iron catalyst effects the homogeneous hydrogenation of ketones under very mild conditions (see scheme). A mechanism including the insertion of the ketone into the Fe[BOND]H bond, followed by addition of hydrogen to a dearomatized intermediate is proposed.