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Tunable, Discrete, Three-Dimensional Hybrid Nanoarchitectures

Authors

  • Dr. Feng Li,

    1. Division of Nanobiomedicine andi-Lab, Suzhou Institute of Nano-Tech and Nano-Bionics, Chinese Academy of Sciences, Suzhou, 215123 (China), Fax: (+86) 512-6287-2620
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  • Ding Gao,

    1. State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, 430071 (China), Fax: (+86) 27-8719-9492
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  • Dr. Xiaomin Zhai,

    1. Division of Nanobiomedicine andi-Lab, Suzhou Institute of Nano-Tech and Nano-Bionics, Chinese Academy of Sciences, Suzhou, 215123 (China), Fax: (+86) 512-6287-2620
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  • Yanhua Chen,

    1. Division of Nanobiomedicine andi-Lab, Suzhou Institute of Nano-Tech and Nano-Bionics, Chinese Academy of Sciences, Suzhou, 215123 (China), Fax: (+86) 512-6287-2620
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  • Dr. Tao Fu,

    1. Division of Nanobiomedicine andi-Lab, Suzhou Institute of Nano-Tech and Nano-Bionics, Chinese Academy of Sciences, Suzhou, 215123 (China), Fax: (+86) 512-6287-2620
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  • Prof. Dr. Dongmin Wu,

    1. Division of Nanobiomedicine andi-Lab, Suzhou Institute of Nano-Tech and Nano-Bionics, Chinese Academy of Sciences, Suzhou, 215123 (China), Fax: (+86) 512-6287-2620
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  • Prof. Zhi-Ping Zhang,

    1. State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, 430071 (China), Fax: (+86) 27-8719-9492
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  • Prof. Dr. Xian-En Zhang,

    Corresponding author
    1. State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, 430071 (China), Fax: (+86) 27-8719-9492
    • State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, 430071 (China), Fax: (+86) 27-8719-9492
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  • Prof. Dr. Qiangbin Wang

    Corresponding author
    1. Division of Nanobiomedicine andi-Lab, Suzhou Institute of Nano-Tech and Nano-Bionics, Chinese Academy of Sciences, Suzhou, 215123 (China), Fax: (+86) 512-6287-2620
    • Division of Nanobiomedicine andi-Lab, Suzhou Institute of Nano-Tech and Nano-Bionics, Chinese Academy of Sciences, Suzhou, 215123 (China), Fax: (+86) 512-6287-2620
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  • F.L. acknowledges funding by NSFC (Grant No. 31040032); Q.W acknowledges funding by the “Bairen Ji Hua” program from CAS, MOST (Grant No. 2011CB965004), NSFC (Grant No. 20173225, 91023038), and CAS/SAFEA International Partnership Program for Creative Research Teams; Z.Z. thanks funding by MOST (Grant No. 2011CB933600). The authors thank Peidong Yang at UC Berkeley for helpful discussions; Gang Ji and Lijun Bi at Institute of Biophysics, CAS for assistance in cryo-TEM sampling and testing; Haomiao Zhu and Xueyuan Chen at Fujian Institute of Research on the Structure of Matter, CAS for help with time-resolved fluorescence measurement; and Wen Zhao for 3D drawings. The authors express their appreciation to Electron Microscope Lab at Suzhou Institute of Nano-Tech and Nano-Bionics, CAS for the TEM facilities used in this research.

Abstract

original image

Virus-based nanoparticle scaffolds (VNPs) were used for two-step construction of discrete 3D nanoarchitectures (see picture): 1) loading of quantum dots (QDs) into VNPs formed by cysteine-modified capsid protein VP1 of simian virus 40; 2) attaching controlled numbers of Au nanoparticles (AuNPs) to VNP surfaces through Au[BOND]S bond formation.

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