Design of Highly Emissive Polymer Dot Bioconjugates for In Vivo Tumor Targeting


  • This work was supported by the National Institutes of Health (CA147837 and NS062725 to D.T.C.; CA135491 and CA112350-03 to J.M.O.; GM 081040 to J.D.M.). We acknowledge support from the Keck Imaging Center, the Center of Nanotechnology at the University of Washington, and the Seattle Children’s Research Institute Brain Tumor Endowment.


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Lighting up brain tumors: Highly fluorescent nanodots that consist of semiconducting polymer blends were attached to the peptide ligand chlorotoxin. The nanodot–chlorotoxin conjugates were specifically targeted to malignant brain tumors in a transgenic mouse model, thus proving their potential as in vivo probes for clinical cancer diagnostics (see picture).