Communication

Design of Highly Emissive Polymer Dot Bioconjugates for In Vivo Tumor Targeting†

  1. Changfeng Wu1,
  2. Stacey J. Hansen2,
  3. Prof. Qiong Hou4,
  4. Jiangbo Yu3,
  5. Maxwell Zeigler1,
  6. Yuhui Jin1,
  7. Daniel R. Burnham1,
  8. Prof. Jason D. McNeill3,
  9. Prof. James M. Olson2,
  10. Prof. Daniel T. Chiu1,*

Article first published online: 4 MAR 2011

DOI: 10.1002/anie.201007461

Issue

Angewandte Chemie International Edition

Angewandte Chemie International Edition

Volume 50, Issue 15, pages 3430–3434, April 4, 2011

Additional Information

How to Cite

Wu, C., Hansen, S. J., Hou, Q., Yu, J., Zeigler, M., Jin, Y., Burnham, D. R., McNeill, J. D., Olson, J. M. and Chiu, D. T. (2011), Design of Highly Emissive Polymer Dot Bioconjugates for In Vivo Tumor Targeting. Angew. Chem. Int. Ed., 50: 3430–3434. doi: 10.1002/anie.201007461

Author Information

  1. 1

    Department of Chemistry, University of Washington, Seattle, WA 98195 (USA), Fax: (+1) 206-685-8665

  2. 2

    Clinical Research Division, Fred Hutchinson Cancer Research Centre, Seattle, WA 98109 (USA)

  3. 3

    Department of Chemistry, Clemson University, Clemson, SC 29634 (USA)

  4. 4

    School of Chemistry and Environment, South China Normal University, Guangzhou, Guangdong 510631 (China)

*Department of Chemistry, University of Washington, Seattle, WA 98195 (USA), Fax: (+1) 206-685-8665

  1. †

    This work was supported by the National Institutes of Health (CA147837 and NS062725 to D.T.C.; CA135491 and CA112350-03 to J.M.O.; GM 081040 to J.D.M.). We acknowledge support from the Keck Imaging Center, the Center of Nanotechnology at the University of Washington, and the Seattle Children’s Research Institute Brain Tumor Endowment.

Publication History

  1. Issue published online: 31 MAR 2011
  2. Article first published online: 4 MAR 2011
  3. Manuscript Revised: 7 FEB 2011
  4. Manuscript Received: 28 NOV 2010

Funded by

  • National Institutes of Health. Grant Numbers: CA147837, NS062725, CA135491, CA112350-03, GM 081040
  • Keck Imaging Center
  • Center of Nanotechnology at the University of Washington
  • Seattle Children’s Research Institute Brain Tumor Endowment

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Keywords:

  • fluorescence;
  • imaging agents;
  • nanoparticles;
  • semiconducting polymers;
  • tumors
Thumbnail image of graphical abstract

Lighting up brain tumors: Highly fluorescent nanodots that consist of semiconducting polymer blends were attached to the peptide ligand chlorotoxin. The nanodot–chlorotoxin conjugates were specifically targeted to malignant brain tumors in a transgenic mouse model, thus proving their potential as in vivo probes for clinical cancer diagnostics (see picture).

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