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Keywords:

  • farinosone A;
  • militarinone D;
  • neurite outgrowth;
  • neurochemistry;
  • pyridone alkaloids
Thumbnail image of graphical abstract

Unus pro omnibus: The development of compounds inducing neurite outgrowth might constitute a valuable approach for the non-invasive medical treatment of neurodegenerative diseases. With the aid of a bifunctional building block, the total syntheses of a group of pyridone polyenes originally produced by entomopathogenic fungi was achieved (see picture). All of these natural products displayed neuritogenic activity in the PC-12 cell line.