Perhaloalkylation of Metal Enolates—Unconventional and Versatile


  • We acknowledge generous funding from the Institute of Organic Chemistry and Biochemistry of the Academy of Sciences of the Czech Republic (Z4 055 0506) and the Grant Agency of the Czech Republic (203/09/1936).


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Radically unconventional: Natural products with di- and trichloromethyl groups and trifluoromethylated pharmaceuticals and agrochemicials are interesting compounds, often with intriguing properties. These types of compounds can be prepared by the direct perhaloalkylation of carbonyl compounds in which enolate reactivity and radical reactivity are merged (see scheme; Bn=benzyl).