We thank the Advanced Light Microscopy Facility at EMBL and Heike Stichnoth for providing cells. Funding was partially provided by SBCancer, the ESF, and the DFG(Schu843/8-1). M.M. is a fellow of the EMBL interdisciplinary postdoc program (EIPOD).
Photoactivatable and Cell-Membrane-Permeable Phosphatidylinositol 3,4,5-Trisphosphate†
Article first published online: 14 MAR 2011
Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 50, Issue 16, pages 3811–3814, April 11, 2011
How to Cite
Mentel, M., Laketa, V., Subramanian, D., Gillandt, H. and Schultz, C. (2011), Photoactivatable and Cell-Membrane-Permeable Phosphatidylinositol 3,4,5-Trisphosphate. Angew. Chem. Int. Ed., 50: 3811–3814. doi: 10.1002/anie.201007796
- Issue published online: 5 APR 2011
- Article first published online: 14 MAR 2011
- Manuscript Received: 10 DEC 2010
- DFG. Grant Number: Schu843/8-1
- EMBL interdisciplinary postdoc program (EIPOD)
- caged compounds;
- signal transduction
Unleashed inside cells: The signaling molecule PI(3,4,5)P3 is prepared in a form that allows its cellular uptake and subsequent activation by light (see picture). The rapid eight-step synthetic sequence yields a stable derivative of the signaling molecule with high biological activity after deprotection (“uncaging”) with a laser flash, in live cells.