Synchronized Inductive Desorption Electrospray Ionization Mass Spectrometry

Authors

  • Guangming Huang,

    1. Department of Chemistry and Center for Analytical Instrumentation Development, Purdue University, West Lafayette, IN 47907 (USA), Fax: (+1) 765-494-9421
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  • Guangtao Li,

    1. Department of Chemistry and Center for Analytical Instrumentation Development, Purdue University, West Lafayette, IN 47907 (USA), Fax: (+1) 765-494-9421
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  • Jason Ducan,

    1. Department of Chemistry and Center for Analytical Instrumentation Development, Purdue University, West Lafayette, IN 47907 (USA), Fax: (+1) 765-494-9421
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  • Zheng Ouyang,

    1. Department of Chemistry and Center for Analytical Instrumentation Development, Purdue University, West Lafayette, IN 47907 (USA), Fax: (+1) 765-494-9421
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  • Prof.  R. Graham Cooks

    Corresponding author
    1. Department of Chemistry and Center for Analytical Instrumentation Development, Purdue University, West Lafayette, IN 47907 (USA), Fax: (+1) 765-494-9421
    • Department of Chemistry and Center for Analytical Instrumentation Development, Purdue University, West Lafayette, IN 47907 (USA), Fax: (+1) 765-494-9421
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  • This research was supported by Office of Naval Research, Research Tools Program (N00014-05-1-0454).

Abstract

original image

Well-orchestrated: A new mass spectrometry protocol (see picture) synchronizes microdroplet creation, nebulizing gas pulsing, and DAPI interface opening. A number of advances result: 100-fold improved detection limit, simultaneous positive and negative ion spectra, and decreased spray volumes in desorption electrospray ionization (DESI).

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