Communication

Inhibition of Amyloid Peptide Fibrillation by Inorganic Nanoparticles: Functional Similarities with Proteins†

  1. Prof. Seong Il Yoo2,3,
  2. Dr. Ming Yang1,
  3. Dr. Jeffrey R. Brender4,
  4. Dr. Vivekanandan Subramanian4,
  5. Dr. Kai Sun5,
  6. Dr. Nam Eok Joo6,
  7. Prof. Soo-Hwan Jeong7,
  8. Prof. Ayyalusamy Ramamoorthy4,
  9. Prof. Nicholas A. Kotov1,*

Article first published online: 14 APR 2011

DOI: 10.1002/anie.201007824

Issue

Angewandte Chemie International Edition

Angewandte Chemie International Edition

Volume 50, Issue 22, pages 5110–5115, May 23, 2011

Additional Information

How to Cite

Yoo, S. I., Yang, M., Brender, J. R., Subramanian, V., Sun, K., Joo, N. E., Jeong, S.-H., Ramamoorthy, A. and Kotov, N. A. (2011), Inhibition of Amyloid Peptide Fibrillation by Inorganic Nanoparticles: Functional Similarities with Proteins. Angew. Chem. Int. Ed., 50: 5110–5115. doi: 10.1002/anie.201007824

Author Information

  1. 1

    Department of Chemical Engineering, Materials Science and Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109 (USA)

  2. 2

    Department of Chemical Engineering, University of Michigan, Ann Arbor, MI 48109 (USA)

  3. 3

    Department of Polymer Engineering, Pukyong National University, Busan 608-739 (Republic of Korea)

  4. 4

    Department of Chemistry and Biophysics, University of Michigan, Ann Arbor, MI 48109 (USA)

  5. 5

    Department of Materials Science and Engineering, University of Michigan, Ann Arbor, MI 48109 (USA)

  6. 6

    Department of Periodontics and Oral Medicine, School of Dentistry, University of Michigan, Ann Arbor, MI 48109 (USA)

  7. 7

    Department of Chemical Engineering, Kyoungpook National University, Daegu 702-701 (Korea)

*Department of Chemical Engineering, Materials Science and Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109 (USA)

  1. †

    This work was supported by the NSF (grant numbers 0932823, 0933384, and 0938019), the NIH (grant numbers 1R21CA121841-01A2 and 5R01EB007350-02), and in part by the DARPA (grant number W31P4Q-08-C-0426). S.I.Y. acknowledges the support of the Korea Research Foundation (grant number KRF-2008-357-D00078).

Publication History

  1. Issue published online: 16 MAY 2011
  2. Article first published online: 14 APR 2011
  3. Manuscript Received: 12 DEC 2010

Funded by

  • NSF. Grant Numbers: 0932823, 0933384, 0938019
  • NIH. Grant Numbers: 1R21CA121841-01A2, 5R01EB007350-02
  • DARPA. Grant Number: W31P4Q-08-C-0426
  • Korea Research Foundation. Grant Number: KRF-2008-357-D00078

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Keywords:

  • fibrils;
  • nanoparticles;
  • peptides;
  • self-assembly
Thumbnail image of graphical abstract

Nanoparticles for amyloid diseases: CdTe nanoparticles (NPs) can efficiently prevent fibrillation of amyloid peptides; the process is based on the multiple binding of Aβ oligomers to CdTe NPs. The molar efficiency and the inhibition mechanism displayed by the NPs are analogous to the mechanism found for proteins responsible for the prevention of amyloid fibrillation in the human body.

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