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Nonenzymatic Dynamic Kinetic Resolution of α-(Arylthio)- and α-(Alkylthio)alkanoic Acids


  • We gratefully acknowledge the financial support of this study by the National Science Foundation (CHE 1012979).


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Dynamic solution: The title acids undergo dynamic kinetic resolution during an enantioselective esterification catalyzed by (S)-homobenzotetramisole ((S)-HBTM; see scheme). This method extends the scope of the carboxylic acid derivatives that are amenable to the nonenzymatic version of this transformation.