• Open Access

Synthesis of 64CuII–Bis(dithiocarbamatebisphosphonate) and Its Conjugation with Superparamagnetic Iron Oxide Nanoparticles: In Vivo Evaluation as Dual-Modality PET–MRI Agent

Authors


  • This work was funded by the KCL Centre of Excellence in Medical Engineering funded by the Wellcome Trust and the EPSRC under grant WT 088641/Z/09/Z. The authors are also grateful for support from the KCL-UCL Comprehensive Cancer Imaging Centre, funded by CRUK and APSRC, in association with the MRC and DoH (England), Guy’s and St. Thomas’ Charity, the Department of Health’s NIHR Biomedical Research Centres funding scheme, an EPSRC Fellowship (to M.J.O.), and the Wellcome Trust for an equipment grant supporting the purchase of the PET-CT scanner. We thank D. Thakor and K. Sunassee for technical support and K. Shaw for 64Cu production. PET=positron emission tomography, MRI=magnetic resonance imaging.

Abstract

original image

A novel bifunctional chelator combines a dithiocarbamate group for binding the positron-emitter 64Cu (red spheres) for PET imaging and a bisphosphonate group (green ellipsoids) for strong binding to several inorganic materials, such as MRI contrast agents based on superparamagnetic iron oxide nanoparticles and rare-earth metal oxides. The dual PET–MR imaging capabilities of this approach are demonstrated in vivo by imaging lymph nodes using both imaging modalities.

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