Get access

Reply to T. W. Bentley: Limitations of the s(E+N) and Related Equations

Authors

  • Prof. Dr. Herbert Mayr

    Corresponding author
    1. Department Chemie, Ludwig-Maximilians-Universität München, Butenandtstrasse 5–13 (Haus F), 81377 München (Germany), Fax: (+49) 89-2180-77717
    • Department Chemie, Ludwig-Maximilians-Universität München, Butenandtstrasse 5–13 (Haus F), 81377 München (Germany), Fax: (+49) 89-2180-77717
    Search for more papers by this author

  • I very much appreciate the invaluable help of Dr. Tanja Kanzian, Dipl.-Ing. Johannes Ammer, and Dr. Armin Ofial in preparing this reply. s=slope, E=electrophilicity, N=nucleophilicity.

Abstract

original image

Simple and unambiguous: In the equation log k=s(E+N), the nucleophilicity N is obtained through the intercepts on the abscissa of linear log k versus E (electrophilicity) correlations. This approach places nucleophiles that differ by more than 30 orders of magnitude in reactivity on a single scale that can be used as a guide for designing organic syntheses. The equation in question is not only more practical but is also more precise than Bentley's alternatives.

Get access to the full text of this article

Ancillary