Self-Assembly of a Bifunctional DNA Carrier for Drug Delivery

Authors

  • Dr. Kelong Wang,

    1. Center For Research at Bio/nano Interface, Department of Chemistry and Department of Physiology and Functional Genomics, Shands Cancer Center, UF Genetics Institute and McKnight Brain Institute, University of Florida, Gainesville, FL 322611-7200 (USA), Fax: (+1) 352-846-2410
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  • Mingxu You,

    1. Center For Research at Bio/nano Interface, Department of Chemistry and Department of Physiology and Functional Genomics, Shands Cancer Center, UF Genetics Institute and McKnight Brain Institute, University of Florida, Gainesville, FL 322611-7200 (USA), Fax: (+1) 352-846-2410
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  • Dr. Yan Chen,

    1. Center For Research at Bio/nano Interface, Department of Chemistry and Department of Physiology and Functional Genomics, Shands Cancer Center, UF Genetics Institute and McKnight Brain Institute, University of Florida, Gainesville, FL 322611-7200 (USA), Fax: (+1) 352-846-2410
    2. State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Biology and College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082 (P.R. China)
    3. State Key Laboratory of Physical Chemistry of Solid Surfaces, The Key Laboratory for Chemical Biology of Fujian Province, The Key Laboratory of Analytical Sciences and Department of Chemical Biology, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005 (China), Fax: (+86) 592-218-9959
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  • Da Han,

    1. Center For Research at Bio/nano Interface, Department of Chemistry and Department of Physiology and Functional Genomics, Shands Cancer Center, UF Genetics Institute and McKnight Brain Institute, University of Florida, Gainesville, FL 322611-7200 (USA), Fax: (+1) 352-846-2410
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  • Zhi Zhu,

    1. Center For Research at Bio/nano Interface, Department of Chemistry and Department of Physiology and Functional Genomics, Shands Cancer Center, UF Genetics Institute and McKnight Brain Institute, University of Florida, Gainesville, FL 322611-7200 (USA), Fax: (+1) 352-846-2410
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  • Jin Huang,

    1. Center For Research at Bio/nano Interface, Department of Chemistry and Department of Physiology and Functional Genomics, Shands Cancer Center, UF Genetics Institute and McKnight Brain Institute, University of Florida, Gainesville, FL 322611-7200 (USA), Fax: (+1) 352-846-2410
    2. State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Biology and College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082 (P.R. China)
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  • Dr. Kathryn Williams,

    1. Center For Research at Bio/nano Interface, Department of Chemistry and Department of Physiology and Functional Genomics, Shands Cancer Center, UF Genetics Institute and McKnight Brain Institute, University of Florida, Gainesville, FL 322611-7200 (USA), Fax: (+1) 352-846-2410
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  • Prof. Chaoyong James Yang,

    Corresponding author
    1. State Key Laboratory of Physical Chemistry of Solid Surfaces, The Key Laboratory for Chemical Biology of Fujian Province, The Key Laboratory of Analytical Sciences and Department of Chemical Biology, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005 (China), Fax: (+86) 592-218-9959
    • State Key Laboratory of Physical Chemistry of Solid Surfaces, The Key Laboratory for Chemical Biology of Fujian Province, The Key Laboratory of Analytical Sciences and Department of Chemical Biology, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005 (China), Fax: (+86) 592-218-9959
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  • Prof. Dr. Weihong Tan

    Corresponding author
    1. Center For Research at Bio/nano Interface, Department of Chemistry and Department of Physiology and Functional Genomics, Shands Cancer Center, UF Genetics Institute and McKnight Brain Institute, University of Florida, Gainesville, FL 322611-7200 (USA), Fax: (+1) 352-846-2410
    2. State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Biology and College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082 (P.R. China)
    • Center For Research at Bio/nano Interface, Department of Chemistry and Department of Physiology and Functional Genomics, Shands Cancer Center, UF Genetics Institute and McKnight Brain Institute, University of Florida, Gainesville, FL 322611-7200 (USA), Fax: (+1) 352-846-2410
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  • We thank the NIH for supporting this work. This work was also supported by the National Key Scientific Program of China (2011CB911000) and China National Grand Program on Key Infectious Disease (2009ZX10004-312). China National Scientific Foundation of China (20805038, 20620130427), and National Basic Research Program of China (2007CB935603, 2010CB732402).

Abstract

original image

Speedy delivery: A self-assembled bifunctional unit incorporates a DNA aptamer for target recognition (see picture, green helix) and a G-quadruplex for drug loading. The modified DNA selectively delivered a photosensitizer (red bars) to cancer cells; irradiation with visible light generated high toxicity.

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