Palladium-Catalyzed Aerobic Oxidative Direct Esterification of Alcohols


  • This work was supported by the National Natural Science Foundation of China (20772093, 20972118, and 20832003), the Fundamental Research Funds for the Central Universities, and Program for New Century Excellent Talents in University. We thank Prof. Xinquan Hu (Zhejiang University of Technology) for providing several benzylic alcohols as gifts. We thank Prof. Matthias Beller (Rostock University) for sharing information on work in this area.


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One step from alcohol to ester: A palladium-catalyzed oxidative esterification of various benzylic alcohols with methanol and long-chain aliphatic alcohols was carried out in the presence of molecular oxygen as the oxidant (see scheme). By considering the effects of substitution and potential mechanistic pathways, the applicability of this method to a range of different substrates was shown.