A good impression: A modular approach using a ruthenium(II) catalyst during peptide synthesis gives rigid and well-defined triazole bridges as tailor-made substitutes for natural disulfide bridges (see structures). The corresponding modification of the monocyclic sunflower trypsin inhibitor-1 yielded an equally potent peptidomimetic containing a redox stable 1,5-disubstituted 1,2,3-triazole bridge.
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