The SRO Bionano of MESA+ is acknowledged for financial support. A.S. acknowledges funding from the European Community Seventh Framework Program under the grant agreement CP-FP 228622-2 MAGNIFYCO.
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Communication
Multivalent Nanoparticle Networks as Ultrasensitive Enzyme Sensors†
Article first published online: 17 MAY 2011
DOI: 10.1002/anie.201008189
Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Additional Information
How to Cite
de laRica, R., Fratila, R. M., Szarpak, A., Huskens, J. and Velders, A. H. (2011), Multivalent Nanoparticle Networks as Ultrasensitive Enzyme Sensors. Angew. Chem. Int. Ed., 50: 5704–5707. doi: 10.1002/anie.201008189
- †
Publication History
- Issue published online: 7 JUN 2011
- Article first published online: 17 MAY 2011
- Manuscript Received: 26 DEC 2011
- Manuscript Revised: 23 FEB 2011
Funded by
- SRO Bionano of MESA+
- European Community Seventh Framework Program. Grant Number: CP-FP 228622-2 MAGNIFYCO
Keywords:
- biosensors;
- cyclodextrins;
- enzymes;
- gold;
- supramolecular chemistry
As few as 23 enzyme molecules could be detected on the basis of the dispersion of Au nanoparticles in a model bioassay whose sensitivity was boosted by the interplay between multivalent and monovalent supramolecular interactions: a diferrocenyl ligand (red) caused the assembly of nanoparticle clusters; upon its oxidation, a competing monovalent guest molecule (blue) favored the formation of monovalent interactions for more efficient disassembly.