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The Amyloid–Congo Red Interface at Atomic Resolution


  • This work was supported by the ETH Zurich, the Swiss National Science Foundation (Grant 200020_124611), the CNRS, and the Agence Nationale de la Recherche (ANR-07-PCVI-0013-03, ANR-06-BLAN-0266, ANR-PCV08 321323, and ANR08-PCVI-0022-02). We also acknowledge support from the European Commission under the Seventh Framework Programme (FP7), contract Bio-NMR 261863.


original image

The analytical “gold standard” for amyloid characterization and diagnostics, Congo red, was studied in complex with an amyloid (see picture). Based on details of the binding mode, a point mutation of the amyloid was prepared which has the same three-dimensional structure as the wild-type protein but is not congophilic. This surprising specificity may aid in the design of selective anti-amyloidogenic drugs.