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Phosphorescent Nanoscale Coordination Polymers as Contrast Agents for Optical Imaging

Authors


  • We thank the NIH-NCI (U01-CA151455) for financial support and Mr. Caleb A. Kent and Cheng Wang for experimental help.

Abstract

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Seeing is believing: Phosphorescent nanoscale coordination polymers (NCPs) with unprecedentedly high dye loadings were coated with thin silica shells to tune the dye release kinetics (see picture). Further functionalization of the NCP/silica particles with poly(ethylene glycol) (PEG) and PEG-anisamide enhanced their biocompatibility and targeting ability, allowing cancer-specific imaging of human lung cancer H460 cells.

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