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Keywords:

  • allylation;
  • enantioselectivity;
  • iridium complexes;
  • transfer hydrogenation;
  • trifluoromethyl
Thumbnail image of graphical abstract

A flourish of fluorine: Exposure of α-trifluoromethyl allyl benzoate to alcohols in the presence of an ortho-cyclometalated iridium catalyst results in the generation of aldehyde–allyliridium intermediates to form enantiomerically enriched products of anti-(α-trifluoromethyl)allylation. An identical set of products is obtained from aldehydes under related transfer hydrogenation conditions employing isopropyl alcohol as terminal reductant.