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One-Pot Reactions Accelerate the Synthesis of Active Pharmaceutical Ingredients


  • We thank the Fonds der Chemischen Industrie for financial support (Dozentenstipendium to M.C. and Chemiefonds-Stipendium to P.W.).


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All in one: A one-pot synthesis of the dipeptidylpeptidase IV selective inhibitor ABT-341 (see structure) by using an “uninterrupted sequence of reactions” has been developed. This strategy broadens the spectrum of one-pot reactions and is poised to speed up the synthesis of medicinally relevant drug compounds.