Expanding the Enzyme Toolbox for Biocatalysis

Authors

  • Dr. Jacob E. Vick,

    1. Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, 1479 Gortner Ave, Saint Paul, MN 55106 (USA), Fax: (+1) 612-625-5780
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  • Prof. Dr. Claudia Schmidt-Dannert

    Corresponding author
    1. Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, 1479 Gortner Ave, Saint Paul, MN 55106 (USA), Fax: (+1) 612-625-5780
    • Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, 1479 Gortner Ave, Saint Paul, MN 55106 (USA), Fax: (+1) 612-625-5780
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Abstract

original image

We've got talent: New enzymes with novel reactivity are constantly added to the enzyme toolbox as exemplified by the berberine bridge enzyme (BBE). Analogues of 2, which are bioactive, have been successfully made from analogues of 1 using BBE. Such new enzymes hold the promise of convenient synthesis of potentially useful nonnatural products.

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