Highly Magnetic Core–Shell Nanoparticles with a Unique Magnetization Mechanism

Authors

  • Prof. Dr. Tae-Jong Yoon,

    1. Center for Systems Biology, Massachusetts General Hospital/Harvard Medical School, 185 Cambridge Street, Boston, MA 02114 (USA), Fax: (+1) 617-643-6133
    2. Present address: Department of Applied Bioscience, CHA University, Seoul 135-081 (Republic of Korea)
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    • These authors contributed equally to this work

  • Prof. Dr. Hakho Lee,

    Corresponding author
    1. Center for Systems Biology, Massachusetts General Hospital/Harvard Medical School, 185 Cambridge Street, Boston, MA 02114 (USA), Fax: (+1) 617-643-6133
    • Center for Systems Biology, Massachusetts General Hospital/Harvard Medical School, 185 Cambridge Street, Boston, MA 02114 (USA), Fax: (+1) 617-643-6133
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    • These authors contributed equally to this work

  • Huilin Shao,

    1. Center for Systems Biology, Massachusetts General Hospital/Harvard Medical School, 185 Cambridge Street, Boston, MA 02114 (USA), Fax: (+1) 617-643-6133
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  • Prof. Dr. Ralph Weissleder

    Corresponding author
    1. Center for Systems Biology, Massachusetts General Hospital/Harvard Medical School, 185 Cambridge Street, Boston, MA 02114 (USA), Fax: (+1) 617-643-6133
    2. Department of Systems Biology, Harvard Medical School, 200 Longwood Av., Boston, MA 02115 (USA)
    • Center for Systems Biology, Massachusetts General Hospital/Harvard Medical School, 185 Cambridge Street, Boston, MA 02114 (USA), Fax: (+1) 617-643-6133
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  • The authors thank C. Ross (MIT) for her generous support in magnetic measurements; R. Zhang, G. Wojtkiewicz, J. Figueiredo, J. Chen and M. Nahrendorf for their assistance in MRI; N. Sergeyev for synthesizing CLIO; D. Issadore, M. Liong and E. Keliher for helpful discussions; Y. Fisher-Jeffes for reviewing the manuscript. This work was supported by National Institute of Health Grants 2R01-EB004626, U54-CA119349, and TPEN contract (HHSN268201000044C).

Abstract

original image

The potent core: A new approach to preparing highly magnetic nanoparticles consisting of a ferromagnetic core (Fe) and an artificial ferrite shell was developed. The monometallic core contributes to high overall magnetization. The superparamagnetic ferrite shell protects the core against oxidation and further increases magnetization while minimizing particle aggregation.

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