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Micromachine-Enabled Capture and Isolation of Cancer Cells in Complex Media

Authors

  • Dr. Shankar Balasubramanian,

    1. Department of NanoEngineering, University of California—San Diego, La Jolla, CA 92093 (USA), Fax: (+1) 858-534-9553
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    • These authors contributed equally to this work.

  • Daniel Kagan,

    1. Department of NanoEngineering, University of California—San Diego, La Jolla, CA 92093 (USA), Fax: (+1) 858-534-9553
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    • These authors contributed equally to this work.

  • Che-Ming Jack Hu,

    1. Department of NanoEngineering, University of California—San Diego, La Jolla, CA 92093 (USA), Fax: (+1) 858-534-9553
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  • Dr. Susana Campuzano,

    1. Department of NanoEngineering, University of California—San Diego, La Jolla, CA 92093 (USA), Fax: (+1) 858-534-9553
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  • Dr. M. Jesus Lobo-Castañon,

    1. Department of NanoEngineering, University of California—San Diego, La Jolla, CA 92093 (USA), Fax: (+1) 858-534-9553
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  • Nicole Lim,

    1. Department of NanoEngineering, University of California—San Diego, La Jolla, CA 92093 (USA), Fax: (+1) 858-534-9553
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  • Dae Y. Kang,

    1. Department of NanoEngineering, University of California—San Diego, La Jolla, CA 92093 (USA), Fax: (+1) 858-534-9553
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  • Maria Zimmerman,

    1. Department of NanoEngineering, University of California—San Diego, La Jolla, CA 92093 (USA), Fax: (+1) 858-534-9553
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  • Dr. Liangfang Zhang,

    Corresponding author
    1. Department of NanoEngineering, University of California—San Diego, La Jolla, CA 92093 (USA), Fax: (+1) 858-534-9553
    • Department of NanoEngineering, University of California—San Diego, La Jolla, CA 92093 (USA), Fax: (+1) 858-534-9553
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  • Prof. Joseph Wang

    Corresponding author
    1. Department of NanoEngineering, University of California—San Diego, La Jolla, CA 92093 (USA), Fax: (+1) 858-534-9553
    • Department of NanoEngineering, University of California—San Diego, La Jolla, CA 92093 (USA), Fax: (+1) 858-534-9553
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  • This work was supported by the National Science Foundation (award number CBET 0853375 to J.W.) and by the National Institutes of Health (grant number U54A119335 to L.Z.). M.J.L.C. thanks the University of Oviedo and the Spanish MICINN (PR 2009-0430). The authors thank M. Benchimol, B. Chuluun, and Prof. S. Esener for their help.

Abstract

original image

Microrockets detect cancer: A micromachine is used for the in vitro isolation of pancreatic cancer cells in complex media. The strategy is based on the selective binding and transport ability of antibody-functionalized microengine rockets: these microrockets selectively recognize the surface antigens overexpressed by pancreatic cancer cells, and capture and transport the cancer cells over a preselected path (see picture).

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