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Construction and Potential Applications of a Functionalized Cell with an Intracellular Mineral Scaffold

Authors

  • Dr. Xiaoming Ma,

    1. College of Chemistry and Environmental Science, Key Laboratory of Green Chemical Media and Reactions, Ministry of Education, Henan Normal University, Xinxiang, 453007 (P.R. China)
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  • Huifeng Chen,

    1. College of Chemistry and Environmental Science, Key Laboratory of Green Chemical Media and Reactions, Ministry of Education, Henan Normal University, Xinxiang, 453007 (P.R. China)
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  • Prof. Lin Yang,

    Corresponding author
    1. College of Chemistry and Environmental Science, Key Laboratory of Green Chemical Media and Reactions, Ministry of Education, Henan Normal University, Xinxiang, 453007 (P.R. China)
    • College of Chemistry and Environmental Science, Key Laboratory of Green Chemical Media and Reactions, Ministry of Education, Henan Normal University, Xinxiang, 453007 (P.R. China)
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  • Kui Wang,

    1. College of Chemistry and Environmental Science, Key Laboratory of Green Chemical Media and Reactions, Ministry of Education, Henan Normal University, Xinxiang, 453007 (P.R. China)
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  • Dr. Yuming Guo,

    1. College of Chemistry and Environmental Science, Key Laboratory of Green Chemical Media and Reactions, Ministry of Education, Henan Normal University, Xinxiang, 453007 (P.R. China)
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  • Prof. Lan Yuan

    1. Medical and Healthy Analytical Center, Peking University Health Science Center, 38 Xueyuan RD., Beijing, 100191 (P.R. China)
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  • We thank Professor Tianlan Zhang (Peking University), Changjian Lin, and Dr. Ren Hu (Xiamen University) for assistance in the characterization studies, and Professor Zhenyu Chen (The Chinese University of Hong Kong) for discussions on the application of the functionalized cells. This work was financially supported by the National Science Foundation of China (grant no. 20771036), the National Key Basic Research and Development Program of China (grant no. 2009CB626610), the Innovation Scientists and Technicians Troop Construction Projects of Henan Province (grant no. 114200510004) and Program for Changjiang Scholars and Innovative Research Team in University.

Abstract

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Growing within: The reaction of added Ca2+ ions with the CO2 produced by respiration results in the endogenous production of a CaCO3 scaffold in functionalized cells (see picture). These cells act as anticancer drug carriers with pH-sensitive release, and can enhance the cytotoxicity of drugs by increasing the cellular uptake. The functionalized cells also have potential applications in heavy-metal extraction.

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