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Electrostatic Control of Bioactivity

Authors

  • Dr. Joshua E. Goldberger,

    1. Department of Chemistry, Northwestern University, Evanston, IL 60208 (USA), Fax: (+1) 847-491-3010
    2. Current address: Department of Chemistry, The Ohio State University, Columbus, OH 43210 (USA)
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    • These authors contributed equally.

  • Eric J. Berns,

    1. Department of Biomedical Engineering, Northwestern University, Evanston, IL 60208 (USA)
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    • These authors contributed equally.

  • Dr. Ronit Bitton,

    1. Institute for BioNanotechnology in Medicine, Northwestern University, Chicago, IL 60611 (USA)
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  • Christina J. Newcomb,

    1. Department of Materials Science and Engineering, Northwestern University, Evanston, IL 60208 (USA)
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  • Prof. Samuel I. Stupp

    Corresponding author
    1. Department of Chemistry, Northwestern University, Evanston, IL 60208 (USA), Fax: (+1) 847-491-3010
    2. Department of Materials Science and Engineering, Northwestern University, Evanston, IL 60208 (USA)
    3. Feinberg School of Medicine, Northwestern University, Evanston, IL 60208 (USA)
    • Department of Chemistry, Northwestern University, Evanston, IL 60208 (USA), Fax: (+1) 847-491-3010
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  • The authors acknowledge James Hulvat, Liam Palmer, Hongang Cui, Shantanu Sur, and Sunitha Suresh for helpful discussions. We acknowledge the following Northwestern University facilities: IBNAM Peptide Core, IBNAM Cleanroom Core, Keck, BIF, MRC, Cell Imaging Facility (generously supported by NCI CCSG P30 CA060553 awarded to the Robert H. Lurie Comprehensive Cancer Center), C. Shad Thaxton laboratory (DLS), J. B. Cohen X-Ray Diffraction Facility. We acknowledge financial support by the MRSEC program and the National Science Foundation (DMR-0520513).WAXS was carried out at the Argonne National Laboratory at the BioCARS 14-BM-C beamline. Additional support from the Ben Gurion University in Negev, Israel in the form of a postdoctoral fellowship for R.B. is also acknowledged. This project was supported by the Army Research Office (W911NF-09-1-0044) and the National Institute of Biomedical Imaging and Bioengineering (Award Numbers F32EB007131 and 5 R01EB003806-05). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institute of Biomedical Imaging and Bioengineering or the National Institutes of Health.

Abstract

original image

The power of independence: When exhibited on the surface of self-assembling peptide-amphiphile nanofibers, the hydrophobic laminin-derived IKVAV epitope induced nanofiber bundling through interdigitation with neighboring fibers and thus decreased the bioactivity of the resulting materials. The inclusion of charged amino acids in the peptide amphiphiles disrupted the tendency to bundle and led to significantly enhanced neurite outgrowth (see picture).

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