We thank the National Science Council of China (NSC-99-2811M-007-089) for support of this research.
Regioselective Synthesis of Indenols by Rhodium-Catalyzed CH Activation and Carbocyclization of Aryl Ketones and Alkynes†
Article first published online: 29 MAR 2011
Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 50, Issue 18, pages 4169–4172, April 26, 2011
How to Cite
Muralirajan, K., Parthasarathy, K. and Cheng, C.-H. (2011), Regioselective Synthesis of Indenols by Rhodium-Catalyzed CH Activation and Carbocyclization of Aryl Ketones and Alkynes. Angew. Chem. Int. Ed., 50: 4169–4172. doi: 10.1002/anie.201100229
- Issue published online: 20 APR 2011
- Article first published online: 29 MAR 2011
- Manuscript Received: 11 JAN 2011
- National Science Council of China
- aryl ketones;
- CH activation;
Ketones and alkynes join together: The catalytic title reaction proceeds rapidly at 120 °C and requires only 1 hour for completion (see scheme). The reaction mechanism likely involves chelation-assisted ortho CH activation, insertion of the alkyne moiety, carbocyclization, and protonation. Cp*=pentamethylcyclopentadienyl.