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Photothermal Contrast Reaches Single-Molecule Sensitivity

Authors

  • Prof. Dr. Thomas Basché

    Corresponding author
    1. Institut für Physikalische Chemie, Johannes Gutenberg-Universität Mainz, Welderweg 11, 55128 Mainz (Germany)
    • Institut für Physikalische Chemie, Johannes Gutenberg-Universität Mainz, Welderweg 11, 55128 Mainz (Germany)
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Abstract

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The detection of single-molecule absorption under ambient conditions is a very challenging task, because the tiny change in transmission is difficult to discriminate against the noise from the light beam and from scattering. By pushing the detection limits of photothermal contrast imaging, single-molecule absorption has been measured by the refraction index change induced in the environment by the heat released from the molecule (see image).

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