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Self-Optimizing Continuous Reactions in Supercritical Carbon Dioxide


  • We thank the EPSRC, grant no. EP/D501229/1 (the DICE project), the EU SYNFLOW project, AstraZeneca, and Croda Europe Ltd. for funding. We also thank David Litchfield, James Warren, Peter Fields, Richard Wilson, and Mark Guyler for technical support. We are grateful to Prof. Walter Leitner for suggesting the Simplex algorithm for self-optimization.


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Hands-free optimization: A combination of an automated flow reactor, online analysis, and a control algorithm leads to efficient optimization of reactions to a given product without the need for human intervention.