Terminating Platinum-Initiated Cation-Olefin Reactions with Simple Alkenes


  • We thank the National Institutes of Health, General Medicine (grant no. GM-60578), and the Army Research Office for generous support.


original image

All for one: Phosphine-ligated platinum(II) electrophiles can activate polyalkenes for cyclase enzyme mimicking cascade cyclizations without the need for special terminating groups (see scheme). Like the cyclase enzymes, terminal alkenes that generate tertiary cations are good substrates, although the details of the cation termination depend on the alkene arrangement.