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Keywords:

  • biomimetic synthesis;
  • cascade cyclization;
  • electrophilic activation;
  • platinum
Thumbnail image of graphical abstract

All for one: Phosphine-ligated platinum(II) electrophiles can activate polyalkenes for cyclase enzyme mimicking cascade cyclizations without the need for special terminating groups (see scheme). Like the cyclase enzymes, terminal alkenes that generate tertiary cations are good substrates, although the details of the cation termination depend on the alkene arrangement.