A Biologically Relevant Co1+⋅⋅⋅H Bond: Possible Implications in the Protein-Induced Redox Tuning of Co2+/Co1+ Reduction

Authors

  • Manoj Kumar,

    1. Department of Chemistry, University of Louisville, 2320 South Brook Street, Louisville, KY 40292 (USA)
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  • Prof. Pawel M. Kozlowski

    Corresponding author
    1. Department of Chemistry, University of Louisville, 2320 South Brook Street, Louisville, KY 40292 (USA)
    • Department of Chemistry, University of Louisville, 2320 South Brook Street, Louisville, KY 40292 (USA)
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  • We acknowledge exceptional computational support provided by the Cardinal Research Cluster, University of Louisville.

Abstract

original image

Reduced circumstances: A hydrogen bond induced by the Co+ ion has been identified theoretically (see picture). It plays a vital role in explaining the mechanistic base of protein-induced tuning of the Co2+/Co+ redox process, a common catalytic event in a wide variety of methyltransferases and adenosyltransferases.

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