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Keywords:

  • bacterial detection;
  • biosensors;
  • DNA cleavage;
  • DNAzymes;
  • fluorescence
Thumbnail image of graphical abstract

Lighting up bacteria: An RNA-cleaving fluorescent DNAzyme (RFD) can produce a fluorescent signal in the crude extracellular mixture generated by live bacterial cells (see picture). These DNAzymes cleave a lone RNA linkage (R) embedded in a DNA chain and flanked by nucleotides labeled with a fluorophore (F) and a quencher (Q).