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Simple Synthesis and Functionalization of Iron Nanoparticles for Magnetic Resonance Imaging

Authors

  • Dr. Soshan Cheong,

    1. Industrial Research Limited and The MacDiarmid Institute for Advanced Materials and Nanotechnology, P. O. Box 31-310, Lower Hutt 5040 (New Zealand)
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    • These authors contributed equally to this work.

  • Dr. Peter Ferguson,

    1. Malaghan Institute of Medical Research, P. O. Box 7060, Wellington 6012 (New Zealand)
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    • These authors contributed equally to this work.

  • Dr. Kirk W. Feindel,

    1. School of Chemical and Physical Sciences and The MacDiarmid Institute for Advanced Materials and Nanotechnology, Victoria University of Wellington, Wellington 6012 (New Zealand), Fax: (+64) 4-463-5237
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  • Dr. Ian F. Hermans,

    1. Malaghan Institute of Medical Research, P. O. Box 7060, Wellington 6012 (New Zealand)
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  • Prof. Paul T. Callaghan,

    1. School of Chemical and Physical Sciences and The MacDiarmid Institute for Advanced Materials and Nanotechnology, Victoria University of Wellington, Wellington 6012 (New Zealand), Fax: (+64) 4-463-5237
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  • Dr. Claire Meyer,

    1. Institut Néel (CNRS and UJF), Grenoble (France)
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  • Angela Slocombe,

    1. Department of Radiology, Wellington Hospital, Wellington 6021 (New Zealand)
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  • Dr. Chia-Hao Su,

    1. Center for Translational Research in Biomedical Science, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Kaohsiung 833 (Taiwan)
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  • Prof. Fong-Yu Cheng,

    1. Department of Chemistry and Center for Micro/Nano Technology Research, National Cheng Kung University, Tainan 701 (Taiwan)
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  • Prof. Chen-Sheng Yeh,

    1. Department of Chemistry and Center for Micro/Nano Technology Research, National Cheng Kung University, Tainan 701 (Taiwan)
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  • Dr. Bridget Ingham,

    1. Industrial Research Limited and The MacDiarmid Institute for Advanced Materials and Nanotechnology, P. O. Box 31-310, Lower Hutt 5040 (New Zealand)
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  • Dr. Michael F. Toney,

    1. Stanford Synchrotron Radiation Lightsource, SLAC National Accelerator Laboratory, Menlo Park, CA 94025 (USA)
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  • Prof. Richard D. Tilley

    Corresponding author
    1. School of Chemical and Physical Sciences and The MacDiarmid Institute for Advanced Materials and Nanotechnology, Victoria University of Wellington, Wellington 6012 (New Zealand), Fax: (+64) 4-463-5237
    • School of Chemical and Physical Sciences and The MacDiarmid Institute for Advanced Materials and Nanotechnology, Victoria University of Wellington, Wellington 6012 (New Zealand), Fax: (+64) 4-463-5237
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  • This research was supported by the Foundation for Science, Research and Technology through grant PROJ-13733-NMTS. P.F. thanks the Health Research Council and the Wellington Medical Research Foundation for funding. K.W.F. thanks the Natural Sciences and Engineering Research Council of Canada (NSERC) for funding. Portions of this research were carried out at the Stanford Synchrotron Radiation Lightsource, a national user facility operated by Stanford University on behalf of the U.S. Department of Energy, Office of Basic Energy Sciences.

Abstract

original image

Visualizing small tumors: A novel, facile synthesis leads to the formation of strongly magnetic single-crystal core/shell iron/iron oxide nanoparticles without the use of highly toxic chemicals. The core/shell nanoparticles are highly effective MRI contrast agents and enable unambiguous detection of small tumors of 1–3 mm in vivo (see picture).

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