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Cover Picture: Multifunctional Capsule-in-Capsules for Immunoprotection and Trimodal Imaging (Angew. Chem. Int. Ed. 10/2011)

Authors

  • Dr. Jaeyun Kim,

    1. Russell H. Morgan Department of Radiology and Radiological Science, Division of MR Research, Institute for Cell Engineering, Cellular Imaging Section, The Johns Hopkins University School of Medicine, Baltimore, MD 21205 (USA), Fax: (+1) 443-287-7945
    2. National Creative Research Initiative Center for Oxide Nanocrystalline Materials, World Class University program of Chemical Convergence for Energy and Environment, School of Chemical and Biological Engineering, Seoul National University, Seoul 151-744 (South Korea), Fax: (+82) 2-886-8457
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  • Dr. Dian R. Arifin,

    1. Russell H. Morgan Department of Radiology and Radiological Science, Division of MR Research, Institute for Cell Engineering, Cellular Imaging Section, The Johns Hopkins University School of Medicine, Baltimore, MD 21205 (USA), Fax: (+1) 443-287-7945
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  • Dr. Naser Muja,

    1. Russell H. Morgan Department of Radiology and Radiological Science, Division of MR Research, Institute for Cell Engineering, Cellular Imaging Section, The Johns Hopkins University School of Medicine, Baltimore, MD 21205 (USA), Fax: (+1) 443-287-7945
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  • Taeho Kim,

    1. Russell H. Morgan Department of Radiology and Radiological Science, Division of MR Research, Institute for Cell Engineering, Cellular Imaging Section, The Johns Hopkins University School of Medicine, Baltimore, MD 21205 (USA), Fax: (+1) 443-287-7945
    2. National Creative Research Initiative Center for Oxide Nanocrystalline Materials, World Class University program of Chemical Convergence for Energy and Environment, School of Chemical and Biological Engineering, Seoul National University, Seoul 151-744 (South Korea), Fax: (+82) 2-886-8457
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  • Dr. Assaf A. Gilad,

    1. Russell H. Morgan Department of Radiology and Radiological Science, Division of MR Research, Institute for Cell Engineering, Cellular Imaging Section, The Johns Hopkins University School of Medicine, Baltimore, MD 21205 (USA), Fax: (+1) 443-287-7945
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  • Dr. Heechul Kim,

    1. Russell H. Morgan Department of Radiology and Radiological Science, Division of MR Research, Institute for Cell Engineering, Cellular Imaging Section, The Johns Hopkins University School of Medicine, Baltimore, MD 21205 (USA), Fax: (+1) 443-287-7945
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  • Dr. Aravind Arepally,

    1. Russell H. Morgan Department of Radiology and Radiological Science, Division of MR Research, Institute for Cell Engineering, Cellular Imaging Section, The Johns Hopkins University School of Medicine, Baltimore, MD 21205 (USA), Fax: (+1) 443-287-7945
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  • Prof. Taeghwan Hyeon,

    Corresponding author
    1. National Creative Research Initiative Center for Oxide Nanocrystalline Materials, World Class University program of Chemical Convergence for Energy and Environment, School of Chemical and Biological Engineering, Seoul National University, Seoul 151-744 (South Korea), Fax: (+82) 2-886-8457
    • National Creative Research Initiative Center for Oxide Nanocrystalline Materials, World Class University program of Chemical Convergence for Energy and Environment, School of Chemical and Biological Engineering, Seoul National University, Seoul 151-744 (South Korea), Fax: (+82) 2-886-8457
    Search for more papers by this author
  • Prof. Jeff W. M. Bulte

    Corresponding author
    1. Russell H. Morgan Department of Radiology and Radiological Science, Division of MR Research, Institute for Cell Engineering, Cellular Imaging Section, The Johns Hopkins University School of Medicine, Baltimore, MD 21205 (USA), Fax: (+1) 443-287-7945
    • Russell H. Morgan Department of Radiology and Radiological Science, Division of MR Research, Institute for Cell Engineering, Cellular Imaging Section, The Johns Hopkins University School of Medicine, Baltimore, MD 21205 (USA), Fax: (+1) 443-287-7945
    Search for more papers by this author

Abstract

original image

The dual shielding of pancreatic islets and multimodal imaging by using capsule-in-capsules is described in the Communication by T. Hyeon et al. on page 2317 ff. The semipermeable outer alginate membrane blocks the penetration of immune cells and antibodies, yet allows unhindered diffusion of nutrients, glucose, oxygen, and insulin produced by the islets. The inner capsule, which contains iron oxide and gold imaging agents, prevents direct exposure of the cells to the nanoparticles.

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