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Keywords:

  • C[BOND]N activation;
  • cross-coupling;
  • homogeneous catalysis;
  • nickel;
  • organozinc reagents
Thumbnail image of graphical abstract

Broad scope and good tolerance: An efficient cross-coupling of aryltrimethylammonium iodide salts with aryl-, methyl-, and benzylzinc chlorides catalyzed by [Ni(PCy3)2Cl2] has been achieved (see scheme). The reaction involves cleavage of the C[BOND]N bond and displays broad substrate scope and good functional group tolerance. NMP=N-methylpyrrolidine.