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Nickel-Catalyzed Cross-Coupling of Aryltrimethylammonium Iodides with Organozinc Reagents

Authors

  • Lan-Gui Xie,

    1. CAS Key Laboratory of Soft Matter Chemistry, Joint laboratory of Green Synthetic Chemistry and Department of Chemistry, University of Science and Technology of China, Hefei, Anhui 230026 (China), Fax: (+86) 551-360-1592
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  • Prof. Dr. Zhong-Xia Wang

    Corresponding author
    1. CAS Key Laboratory of Soft Matter Chemistry, Joint laboratory of Green Synthetic Chemistry and Department of Chemistry, University of Science and Technology of China, Hefei, Anhui 230026 (China), Fax: (+86) 551-360-1592
    • CAS Key Laboratory of Soft Matter Chemistry, Joint laboratory of Green Synthetic Chemistry and Department of Chemistry, University of Science and Technology of China, Hefei, Anhui 230026 (China), Fax: (+86) 551-360-1592
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  • This research was supported by the National Basic Research Program of China (grant no. 2009CB825300) and the National Natural Science Foundation of China (grant no. 20772119).

Abstract

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Broad scope and good tolerance: An efficient cross-coupling of aryltrimethylammonium iodide salts with aryl-, methyl-, and benzylzinc chlorides catalyzed by [Ni(PCy3)2Cl2] has been achieved (see scheme). The reaction involves cleavage of the C[BOND]N bond and displays broad substrate scope and good functional group tolerance. NMP=N-methylpyrrolidine.

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