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Micelle-Based Brain-Targeted Drug Delivery Enabled by a Nicotine Acetylcholine Receptor Ligand

Authors

  • Dr. Changyou Zhan,

    1. School of Pharmacy & Key Laboratory of Smart Drug Delivery, Ministry of Education & PLA, Fudan University, Shanghai 201203 (P.R. China), Fax: (+86) 21-5198-0090
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    • These authors contributed equally to this work.

  • Bian Li,

    1. School of Pharmacy & Key Laboratory of Smart Drug Delivery, Ministry of Education & PLA, Fudan University, Shanghai 201203 (P.R. China), Fax: (+86) 21-5198-0090
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    • These authors contributed equally to this work.

  • Dr. Luojuan Hu,

    1. State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai 201203 (P.R. China)
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  • Dr. Xiaoli Wei,

    1. School of Pharmacy & Key Laboratory of Smart Drug Delivery, Ministry of Education & PLA, Fudan University, Shanghai 201203 (P.R. China), Fax: (+86) 21-5198-0090
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  • Prof. Linyin Feng,

    1. State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai 201203 (P.R. China)
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  • Dr. Wei Fu,

    Corresponding author
    1. School of Pharmacy & Key Laboratory of Smart Drug Delivery, Ministry of Education & PLA, Fudan University, Shanghai 201203 (P.R. China), Fax: (+86) 21-5198-0090
    • School of Pharmacy & Key Laboratory of Smart Drug Delivery, Ministry of Education & PLA, Fudan University, Shanghai 201203 (P.R. China), Fax: (+86) 21-5198-0090
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  • Prof. Weiyue Lu

    Corresponding author
    1. School of Pharmacy & Key Laboratory of Smart Drug Delivery, Ministry of Education & PLA, Fudan University, Shanghai 201203 (P.R. China), Fax: (+86) 21-5198-0090
    • School of Pharmacy & Key Laboratory of Smart Drug Delivery, Ministry of Education & PLA, Fudan University, Shanghai 201203 (P.R. China), Fax: (+86) 21-5198-0090
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  • This work was supported by National Basic Research Program of China (973 Program) 2007CB935800 and 2010CB934000, the “Key New Drug Creation Program” 2009ZX09310-006, and Shanghai Nanotechnology Program (0953nm03300).

Abstract

original image

Candid candoxin: A 16-residue peptide (CDX) that is derived from candoxin binds with a high affinity to nicotinic acetylcholine receptors (see picture), which are highly expressed on the blood–brain barrier. In vivo biodistribution and the anti-glioblastoma effect indicate the potential of CDX as a ligand to enable brain-targeted drug delivery.

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