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Cooperative Transition-Metal and Chiral Brønsted Acid Catalysis: Enantioselective Hydrogenation of Imines To Form Amines

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  • This research has been funded by the State of Mecklenburg-Western Pomerania, the BMBF, and the DFG (Leibniz Prize). We thank Dr. W. Baumann, Dr. C. Fischer, S. Buchholz, S. Schareina, A. Kammer, A. Koch, and S. Rossmeisl (all at the LIKAT) for their excellent technical and analytical support.

Abstract

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Control with an iron hand: A broad range of ketimines underwent enantioselective hydrogenation in the presence of a chiral Brønsted catalyst and a well-defined nonchiral iron catalyst (see scheme). This procedure constitutes an attractive and environmentally favorable alternative to well-established asymmetric hydrogenation reactions with precious-metal catalysts.

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