Near-Infrared-Fluorescence-Enhanced Molecular Imaging of Live Cells on Gold Substrates


  • This work is supported by the National Institutes of Health–National Cancer Institute (NIH-NCI) (grant number 5R01A135109-02) and the National Science Foundation (NSF) (grant number CHE-0639053).


original image

In the best light: Plasmonic gold substrates were used to image cells by near-infrared fluorescence microscopy. Two fluorophores (single-walled carbon nanotubes (SWNTs) functionalized by the RGD sequence as well as the organic fluorophore IR800) tag cells in two different spectral regions. The fluorescence of SWNTs sandwiched between a cell membrane and a gold film was enhanced relative to the fluorescence observed on a quartz substrate (see picture).