This work was supported by the JST, the Uehara Memorial Foundation, and the Global COE program.
A Mitochondrial Surface-Specific Fluorescent Probe Activated by Bioconversion†
Article first published online: 3 MAY 2011
Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 50, Issue 24, pages 5478–5481, June 6, 2011
How to Cite
Kawazoe, Y., Shimogawa, H., Sato, A. and Uesugi, M. (2011), A Mitochondrial Surface-Specific Fluorescent Probe Activated by Bioconversion . Angew. Chem. Int. Ed., 50: 5478–5481. doi: 10.1002/anie.201100935
- Issue published online: 1 JUN 2011
- Article first published online: 3 MAY 2011
- Manuscript Received: 7 FEB 2011
- Uehara Memorial Foundation
- Global COE program
- fluorescent probes;
- live-cell imaging;
Cell-based image screening of 12 000 small molecules with aromatic groups was carried out, and 31 were identified as having potential as fluorescent probes for living cells. One candidate is the first fluorescent probe that specifically stains mitochondrial surfaces. Spectroscopic analyses indicate that the molecule undergoes bioconversion to be fluorescent within cells.