This work was financially supported by KAKENHI and JSPS (predoctoral fellowship for Y. H.), and the “Funding Program for Next Generation World-Leading Researchers”, Cabinet Office, Government of Japan (for H.T.). We thank Prof. K. Umezawa for providing the natural sample of conophylline.
Total Synthesis of (−)-Conophylline and (−)-Conophyllidine†
Article first published online: 15 APR 2011
Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 50, Issue 21, pages 4884–4887, May 16, 2011
How to Cite
Han-ya, Y., Tokuyama, H. and Fukuyama, T. (2011), Total Synthesis of (−)-Conophylline and (−)-Conophyllidine. Angew. Chem. Int. Ed., 50: 4884–4887. doi: 10.1002/anie.201100981
- Issue published online: 6 MAY 2011
- Article first published online: 15 APR 2011
- Manuscript Received: 8 FEB 2011
- cascade reactions;
- natural products;
- total synthesis
Double take: The total syntheses of the title compounds were accomplished in a highly convergent manner. The approach features the regio- and diastereoselective Polonovski–Potier-type reaction for the coupling of two aspidosperma skeletons and the formation of the dihydrofuran ring. Troc=2,2,2-trichloroethoxycarbonyl.