Protein Chemical Synthesis by Ligation of Peptide Hydrazides

Authors


  • This work was supported by NSFC (no. 20802040 and no. 20932006) and the national “973” grants from the Ministry of Science and Technology (no. 2011CB965300).

Abstract

original image

pH determines selectivity: The ligation of peptide hydrazides is a new method for protein chemical synthesis that is complementary to native chemical ligation. Peptide hydrazides may be the long-sought reagent equivalent to a “thioester synthon”, one that is stable to the conditions of native chemical ligation.

Ancillary